St. Louis at San Francisco

San Francisco has a winning record both home and away, and just thumped Washington on the road 27-6. It was a team on which the 49ers could move the football. The Niners face another one here in the Rams, a club ranked #13 against the run and #22 against the pass. The 49ers are 7-1 ATS in their last eight games overall, and are 18-8-1 ATS in their last 27 home games. This is a long road trip for the Rams, a team coming in with a backup QB. Despite winning two in a row, St. Louis has lost three of five games. That includes losses to a pair of powerhouse, physical, defensive teams in Carolina and Seattle while scoring 15 and 9 points and they face another powerhouse defense here in San Francisco, one getting healthier on both sides of ball. San Fran is now #4 defensively against the pass and #12 against the run. The 49ers are 24-8-1 ATS in their last 33 games on grass and match-up great against the visitors, who have a losing road record and rank #15 in rushing and 23rd in passing. When they met earlier this season, San Francisco rolled 35-11 at St. Louis with a 219-18 edge in rushing yards! The Niners are now 31-16 ATS in the Jim Harbaugh era as a favorite in this range (3.5 to 9.5 points). Take the 49ers.