Seattle at San Francisco

Seattle may have the likely MVP in quarterback Russell Wilson, but San Francisco has the MVP defense in this divisional showdown. The 49ers are No. 1 defensively in yards allowed overall and passing yards allowed, second in points surrendered (12.8 per game). San Francisco is the NFL's lone remaining undefeated team and gets some key players back. Left tackle Joe Staley returns from a broken leg, along with fullback Kyle Juszczyk, and right tackle Mike McGlinchey. San Francisco has great balance on offense and faces a Seattle pass defense that is ranked #28, giving up 278 yards per game through the air. Seattle gave up 460 yards passing to Matt Schaub and Atlanta two weeks ago, and come off a 40-34 OT win over Tampa Bay at home allowing 418 yards (319 passing). The home team has covered five of the last seven meetings, and the 49ers are 27-7 ATS on Monday Night. Play San Francisco.