San Francisco at Seattle

Both teams are looking to bounce back this week from upset home losses. San Francisco blew a double-digit lead in the fourth quarter for the second time this season, losing to Arizona, and Seattle QB Geno Smith was sacked seven times in a loss to the New York Giants. The Seahawks will have a problem stopping the 49ers running game as it averages 144 yards per game, and Seattle allows 128. Christian McCaffrey has been out, but the team hasn't missed a beat as Jordan Mason has rushed for 107 yards per game on 5.1 yards per carry with three TDs. Brock Purdy passed for 244 yards and a TD, but also threw two interceptions against the Giants. The Seahawks have allowed 71 points their past two games after giving up a total of just 43 their first three games of the season. San Francisco has won the past five meetings (4-1 ATS) and the Seahawks have averaged only 14.4 points in those games. Seattle is 1-5-1 ATS dating to last season and it has stayed UNDER five of six against NFC West opponents. Take the 49ers and the UNDER.