San Francisco at New York

San Francisco gets a break, not having to travel to the East Coast again for this game as it played on the same field last week in a 31-13 win over the Jets. The 49ers probably wish they were playing somewhere else, though, as they suffered numerous injuries on Sunday, attributing it to the turf. New York has some problems on offense as it has scored only 29 points its first two games, and the Giants lost Saquan Barkley for the season with a torn ACL. New York also placed wide receiver Sterling Shepard on injured reserve with a toe injury so their problems rival the Niners. Nick Mullens will likely start for San Francisco after Jimmy Garoppolo went down with an ankle injury. Mullens started eight games for San Francisco in 2018 and finished with a 90.8 QB rating while completing 64.2 percent of his passes. Mullens threw for 2,277 yards and 13 touchdowns that season. The posted total is relatively low and the Giants faced two good defenses their first two games. The OVER is 8-3-1 in the Niners' last 12 games vs. NFC teams and they are 8-3-1 OVER as favorites. The Giants are 11-5 OVER following a loss and the Giants have gone OVER six years in a row in Week 3. Play the 49ers on the moneyline and the OVER.