San Francisco at Minnesota

A long road trip for San Francisco and a short week, having played on Monday Night. Minnesota plays its home opener, an underdog despite a dominant defensive performance in a 28-6 victory at the Giants. QB Sam Darnold was very good and the defense allowed 240 yards while stuffing the run (74 rush yards allowed, 3.5 yards per carry). The Vikings are 6-0-1 ATS after a win. Minnesota has won five in a row at home against the 49ers and is 10-1 ATS at home versus San Francisco. Play Minnesota.