San Francisco at Los Angeles

A rivalry game and a difficult situational spot for San Francisco. The 49ers traveled to Minnesota Sunday, losing 23-17 as a favorite. The defense allowed 403 yards (146 rushing). The 49ers will be without two of their top pass-catchers in WR Deebo Samuel and star RB Christian McCaffrey to injuries. The defense has some key injuries, as well. Los Angeles plays its home opener after an embarrassing loss at Arizona. They are a big underdog at home despite having a terrific veteran QB in Matthew Stafford (533 yards, 69.7% completions). The Rams have won five of their last six home games and are on an 8-3 ATS run at home. Play Los Angeles.