San Francisco at Los Angeles

The knee-jerk reaction would be to jump on Los Angeles since San Francisco lost Jimmy Garoppolo for the season, but the Chargers defense looked very vulnerable in Sunday's 35-23 loss to the Rams as it allowed 33 first downs and 521 yards. The Chargers have allowed an average of 31 points and their only win was against Buffalo. They sorely miss defensive end Joey Bosa, who is out indefinitely with a foot injury. C.J. Beathard takes over at quarterback for San Francisco and it's not something new for him as he started five games in 2017. The difference this time around is he is used to Kyle Shanahan's offense and has a better team around him. The Chargers are just 1-5-1 their last seven games in September and 9-21 ATS their last 30 home games whether in Los Angeles or San Diego. Philip Rivers went 18-of-30 for 226 yards against the Rams, but he couldn't match the damage done by Rams QB Jared Goff, who torched the Chargers defense to the tune of 354 passing yards and three touchdowns. It's difficult to lay double-digits with the Chargers until they prove they can make some stops defensively. Take the 49ers.