San Francisco at Las Vegas

Las Vegas has named Gardner Minshew as its opening day starter after a 27-12 loss to Dallas in which he completed 10 of 21 for 95 yards. Aiden O'Connell finished 14 of 20 for 96 yards and a TD and an interception, but coach Antonio Pierce is going with the much more experienced quarterback. O'Connell killed his chances when he was picked off and it was run back 69 yards for a touchdown. The Raider defense was torched by third-stringer Trey Lance, who threw for 151 yards and a TD on 15-for-23 passing. The Raiders are 3-11 ATS in Game 3s in preseason and 1-3 ATS the past four preseason meetings with San Francisco although the 49ers are in somewhat of a revenge mode after being blown out 34-7 in the 2023 preseason opener by the Raiders. The 49ers have split their first two games, but they got the money in both, including a 16-10 win over New Orleans in Week 2. Take the 49ers.