San Francisco at Indianapolis

San Francisco's defense has been ahead of the offense. In two games the offense has run for 3.8 and 3.1 yards per rush, with five turnovers, while going 11-of-26 on third down. Injuries have been a concern on offense, so it's going to take some time to get in sync. But the defense has been sharp because they upgraded the depth with defensive tackle DeForest Buckner, DE Arik Armstead, DB Jimmie Ward and linebacker Eli Harold. The defense will do well against a Colts offense that has also been out of sync. They come off a 20-19 win over Baltimore, but the first-team offense gained a total of 44 yards. QB Andrew Luck was 6-of-13 passing for 50 yards, with an interception along with being sacked twice in 23 plays. He was without the second-and third-most important players on offense, receiver T.Y. Hilton (shoulder) and left tackle Anthony Castonzo (hamstring). The offense had just 69 yards rushing, 3.1 yards per carry, and in two games they've turned it over three times while going 10-of-34 on third down. Luck is 12-of-22 for 114 yards in seven series in the preseason and still has yet to display the deep ball. Indianapolis is on a 5-1 run UNDER the total in preseason and this shapes up as another defensive duel. Take the UNDER.