San Francisco at Denver

San Francisco heads out on the road after struggling in Week 1 in their other road game, losing 19-10 at Chicago as a TD favorite. QB Trey Lance (ankle) is out with an injury so backup Jimmy Garoppolo will start. Star TE George Kittle has yet to play with a groin injury. The 49ers are 12-27 ATS on the road after allowing 9 points or fewer in the last game, plus 22-38 ATS away after a win by 14+ points. Denver's defense has been terrific, Top 10 in yards allowed and third in points surrendered (18.9 ppg). The 49ers prefer balance on offense but the Denver defense is third against the run. New QB Russell Wilson (2 TDs, 1 INT) leads a balanced Bronco offense that has thrown more than it has passed with the ground attack averaging 4.9 yards per carry. They've struggled in the red zone so far but that will change as there are so many talented pieces. Play Denver.