San Francisco at Denver

Jimmy Garoppolo is expected to see some action for the first time since his ACL injury last season, but Nick Mullens and C.J. Beathard will get most of the snaps following the 49ers' 17-9 win over Dallas in the first week of preseason. Beathard finished 13 of 17 for 141 yards and a touchdown while Mullens was 11 of 17 for 105 yards, evening Kyle Shanahan's preseason record at 4-4-1 ATS. Denver lost to Seattle in Vic Fangio's second game as head coach, and the Broncos' quarterback depth isn't nearly as experienced with Drew Lock, Kevin Hogan, and Brett Rypien. Lock finished 17 of 28 for 180 yards against the Seahawks while Hogan completed 3 of 7 for 27 yards. Joe Flacco played one series and was 3 of 4 for 19 yards, and he doesn't expect to see much action in this matchup. The Broncos are still adjusting to a new coach and offense while San Francisco wants to continue to build a winning attitude after last year's disappointment and Garoppolo's injury. Take the 49ers.