San Francisco at Cincinnati

This game is a long road trip for San Francisco, and its second straight road game. They may have won by a pair of touchdowns in the opener, but they didn't play well against a rebuilding Tampa Bay team. The 49ers had only 256 total yards and turned it over twice, while the Buccaneers ran for 121 yards. The 49ers are 2-7 ATS on fieldturf, plus 7-3 OVER on fieldturf, and are a road favorite as they head to Cincinnati's home opener. The Bengals are 9-3 ATS at home against a team with a winning road record. Cincinnati rolled up 429 yards and 22 first downs last week at Seattle in a 21-20 loss as a big underdog. QB Andy Dalton was outstanding with 418 yards, two touchdowns and no picks. And the defense was stout, allowing 161 passing yards, and just 72 rushing yards. The Bengals are 21-8-2 ATS in September, plus 9-4 ATS after a spread cover. Cincinnati also ranks in the top 10 in total yards and passing yards, so back the home dog in a high-scoring tilt. Play Cincinnati and OVER.