San Francisco at Buffalo

The 49ers had high hopes this season, but a lot has gone wrong as they sit in last place. Their confidence has been blasted the last two games, losing 20-17 at home to Seattle and a 38-10 loss at Green Bay. Now they take a long road trip to frigid (and first place) Buffalo. San Francisco QBs Brock Purdy and Brandon Allen have combined for 14 TDs and nine interceptions on an offense that is 25th in the red zone. The defense is 26th on third down (43.66%) and 29th in the red zone (67.57%). San Francisco is on a 6-13 ATS run. Buffalo QB Josh Allen (18 TDs, 5 INTs) leads an offense that is third in scoring (29.1 points per game) and sixth in the red zone (63.83%). The talented Bills are playing confidently on a 6-0 SU, 5-1 ATS run while scoring 30 or more points in the last five games. Play Buffalo.