San Francisco at Arizona

San Francisco is a big road favorite on a short week in this divisional rivalry. It's a ball-control offense and only the second time they've been a double-digit favorite. The other time was a 9-0 win over Washington, failing to cover. The 49ers are on a 5-11 spread run against the NFC, 15-32-4 ATS when following a victory of 14+ points, as well as 14-30-1 ATS after getting 350+ total yards in their previous game. The defense is dominant, tops in the NFL in yards allowed, second in points (11 per game). San Francisco is 7-3 UNDER the total after scoring 30+ points in their previous game. Arizona is home with a dynamic young QB in Kyler Murray. The Cardinals are 19-7-2 ATS after allowing more than 250 yards passing in their previous game, plus a 22-10 run UNDER the total at home. Arizona is on a 7-3 ATS run against the 49ers, so back the home dog in a defensive duel. Play Arizona and also take the UNDER.