Philadelphia at San Francisco

Philadelphia can go ball-control with RB Miles Sanders and mobile QB Carson Wentz both averaging five or more yards per carry. The Eagles are #13 in the league in time of possession, plus 78-55 ATS away from home on natural grass. The defense is fifth in the NFL in total yards allowed, Top 10 against the run and the pass. They are a touchdown underdog to a San Francisco team that is home from a two-game road trip to the East Coast, at the Jets and Giants. They lost their only home game, 24-20 to Arizona, as a touchdown favorite. San Francisco has been without starting QB Jimmy Garoppolo with backup Nick Mullens running the offense. Garoppolo has a chance to play this weekend, recovering from a sprained ankle, while All-Pro tight end George Kittle missed the past two games with a sprained knee. The 49ers are 3-12 ATS versus teams that force 0.75 or fewer turnovers per game, so back the well-coached dog in a close one. Play Philadelphia.