New York at Buffalo

No one wants a piece of this Giants team right now, which is why we see a sky-high spread over two touchdowns. But, New York is on a 68-46 spread run on the road in the first half of the season, including 40-23 ATS away from home in October games. Buffalo is a huge favorite but in a difficult situational spot. They played in London last week, a 3,459-mile trip, and looked jet-lagged in a 25-20 loss to Jacksonville as a favorite. The Bills are also in a look-ahead spot with New England on deck, a divisional game, and Buffalo is 1-1 in the AFC East. The Bills are 57-89 ATS after covering in two of their last three. And, early season home favorites coming off a loss lose ATS about 60% of the time in the NFL. Hold your nose, back the big dog here and play New York.