Los Angeles at San Francisco

Los Angeles soared OVER by 36 points in its thrilling 44-42 win over Buffalo on Sunday for its third OVER in four games. The Rams have gone OVER six of seven as underdogs, and the past four meetings with the 49ers have sailed to the high side. Matthew Stafford threw for 320 yards and two TDs against the Bills, and Puka Nacua caught 12 passes for 162 yards for the Rams, who outgained the Bills 457-445. The defense tired late as the Bills outscored the Rams 21-6 in the fourth quarter and nearly pulled out the victory. Now that defense has to play on short rest and the Niners had their best offensive showing of the season while blowing out Chicago 38-13. San Francisco totaled 325 passing yards from Brock Purdy and 131 on the ground. George Kittle had six receptions for 151 yards. The 49ers have allowed 28.6 points per game their past three. Take the OVER.