Los Angeles at San Francisco

Los Angeles has won two of three with the defense playing great in a 19-16 win over Denver and last week's 20-17 at Atlanta. The Chargers are 21-6 UNDER the total after allowing 150+ rushing yards in the last game. San Francisco will attack that run defense as they're a ball control offense under Kyle Shanahan that aims to grind out first downs and chew up the clock, ranked No. 12 in time of possession. In the previous three years, they ranked No. 5, No. 6, and No. 17 in that category. The 49ers are currently No. 1 defensively in total yards allowed and against the run, eighth against the pass, plus seventh with 22 sacks. Chargers QB Justin Herbert's stats (13 TDs, 5 INTs) have been down because of injuries to the downfield passing attack with WRs Keenan Allen and Mike Williams hurting. Williams (ankle) is likely out again while Allen (hamstring) has only played in two games and missed practice this week. Herbert has gone four consecutive games without going over 300 yards and has failed to hit a pass over 20 yards in the last three. And in a game involving NFL teams that average 18-23 points eight contests into the season, the UNDER is 112-64 when the total is between 42.5 and 49. Take Los Angeles/San Francisco UNDER the total.