Los Angeles at San Francisco

The San Diego Chargers have been a perfect 3-0 in the NFL preseason as they head to the final week on the road in San Francisco vs. the 2-1 49ers. Jim Harbaugh is only in his second year at the helm in San Francisco, and beat the Chargers last year in week four at San Diego. The Niners had a 10-point lead that turned into a 3-point win with a late San Diego score with a minute to play. Phillip Rivers did not take a snap in either of their loss to the Niners in either of the two prior seasons, also game fours. Alex Smith completed 8 of 10 passes for the Niners under Harbaugh last year, enough for the edge here. Play on San Francisco.