Los Angeles at San Francisco

San Francisco has won and covered all three games while the Chargers have lost all three with a 0-2-1 ATS record.  Also, the 49ers remember a tough 29-27 loss to the Chargers last September and coach Kyle Shanahan is now 6-4-1 ATS in his two preseasons with the 49ers. San Francisco got a good showing from Jimmy Garoppolo as he went 14-of-20 for 188 yards and a touchdown and he played the entire first half in a 27-17 win over Kansas City. Nick Mullens finished 8-of-11 for 84 yards and the Niners outgained the Chiefs 381-248. The Chargers, obviously, can't wait for the regular season to start as they have shown little interest in preseason games and coach Anthony Lynn is 3-8 in 11 preseason games. Easton Stick was 12-of-16 for 82 yards with a touchdown in the Chargers' 23-15 loss to Seattle.  Tyrod Taylor was 6-of-9 for 61 yards and actually led the Chargers in rushing with 34 yards. These teams played in the 2018 preseason finale and the game went OVER by 9.5 points. Garoppolo possibly could get more playing time in this game. Play the 49ers and the OVER.