Los Angeles at San Francisco

The 49ers have looked awful in two games, but this is a deep, talented team with a hard driving coach in John Harbaugh who came into this preseason 15-11 SU, and 14-12 ATS in August. Remember how bad the Texans looked in the opener? Then they flattened the Falcons last week 32-7. Here we have a San Francisco squad off an embarrassing home loss to Denver 34-0. They opened their brand new stadium and got smoked and now they play their second straight home game. A year ago, after losing to Denver in preseason, they ripped off three wins in a row allowing 13, 14 and 6 points. Into town comes a San Diego team playing its second straight road game, off a 41-14 loss at Seattle. It is not a deep team, a rebuilding one that was #29 against the pass last season. That defense allowed 403 yards last week, including 243 yards rushing at 6.6 yards per carry. Now they face the best offensive line in football, a powerhouse ground attack, a hard-nosed coach, as well as an embarrassed team playing its second straight home contest. These teams met last year in preseason and the 49ers won 41-6 in San Diego! Winning at home will be a breeze, so take the 49ers in this one.