Los Angeles at Houston

This is the first time all season Los Angeles has been a double-digit favorite, and the defense is not elite. They are 21st in yards allowed, fourth-worst versus the run (136.8 yards rushing per game allowed), 26th in points surrendered, and dead last on third-down (49.7%). They come off a tough loss in a big game, losing in OT to rival Kansas City, 34-28. The Chargers will be without three defensive starters, including star pass-rusher Joey Bosa. They're 36-55 ATS after allowing 30+ points. Houston plays its fourth home game in the last five contests and comes off of a 30-16 win at Jacksonville. QB David Mills is getting more comfortable, and speedy WR Brandin Cooks had 102 yards and seven receptions last week, so back the big home dog. Play Houston.