Kansas City at San Francisco

San Francisco is not the same team that lost 25-22 in overtime to the Chiefs for the championship in February. The 49ers still suffer a Super Bowl hangover with a 3-3 record, and they have a plethora of injuries, although they did manage to come out on top in a 36-24 victory over a Seattle team that is also dealing with several defensive injuries. The 49ers are 0-4 ATS in their past four games after scoring more than 30 points in their previous game, 0-5 ATS overall following an ATS win, and 0-6 ATS after any win. Kansas City has covered six straight after totaling more than 350 yards their previous game and the Chiefs have had an extra week to prepare after defeating New Orleans 26-13 on Oct. 7. Patrick Mahomes threw for 331 yards and Kareem Hunt had 102 yards rushing against the Saints. Kansas City has gone UNDER its past five October games and the Chiefs are 6-1 UNDER as favorites of 0.5-3.0 points. Kansas City has stayed UNDER its past three games by an average of 8.8 points and it is 9-1-1 ATS its past 11 games. San Francisco is 0-6 ATS its past six against the AFC West. Take the Chiefs and the UNDER.