Jacksonville at Detroit

Jacksonville has won two of three and is outscoring opponents by +12 for the season. That's the best differential in the AFC South with first-place Tennessee at +4. The Jaguars knocked off the Raiders (27-20) as an underdog, hung in there with Kansas City in a 27-17 loss on the road, then upset the Ravens last week, 28-27. QB Trevor Lawrence (16 TDs, 6 INTs) leads a balanced offense that is Top 10 in total yards, rushing, and yards per carry (4.9). Meanwhile, Detroit is getting outscored by 35 points, the sixth-most in the NFC. The last time they got this much respect from oddsmakers was in Week 4 when, as 4-point chalk, the Lions lost at home to Seattle, 48-45. Detroit's defense is last in the NFL in yards given up (414.5 per game), last on third down (50.75%), and last in points surrendered (28.2 pg). The Lions are 17-41 ATS after having won three of four, plus 21-41 ATS after covering four or five of the last six. Play Jacksonville.