Indianapolis at Tennessee

Indianapolis impressed in the opener, taking the Chargers to overtime as a touchdown underdog. Colts QB Jacoby Brissett was 21-of-27 for 190 yards, two TDs and no picks, while the ground game had 203 yards at 6.3 yards per carry. The Colts have covered seven of eight against winning teams, plus are 37-18 ATS when following a straight-up loss. Tennessee is riding high after destroying the Browns and their first-year coach last week. It's clear the Browns made a terrible coaching hire, so don't overreact to the Titan's 43-13 rout. This is still a plodding, run-first offense that ranked #24 in yards last season, and even after routing the Browns they rank just #22 in total yards. Tennessee is 21-46-4 ATS against the AFC, 16-33-3 ATS versus losing teams, and 14-35-2 ATS after scoring 30+ points in their previous game. And in this division rivalry, the Colts are 12-3 ATS the last 15 meetings. Play Indianapolis.