Indianapolis at Pittsburgh

The talented Colts' offense isn't getting any respect with this betting number, especially against an awful Pittsburgh defense. QB Matt Hasselbeck has been the best backup in the NFL, with the Colts 4-0 his last four starts after guiding Indianapolis to a 25-12 win over Tampa Bay last week. Hasselbeck capped a 315-yard performance by tossing a pair of second-half touchdown passes to T.Y. Hilton as Indianapolis rallied to remain in contention for the division title. Indy has a winning record on the road and is on a 4-0 ATS run. The Colts are also 21-10-1 ATS against the AFC. Pittsburgh is home but has QB concerns with Ben Roethlisberger getting knocked out of last weekend's loss at Seattle with a concussion. He will start, but this is the second time this season he's dealt with serious injuries. Pittsburgh's pass defense will get chewed up by the Colts, surrendering 283.6 yards per game, #30 in the NFL. It let them down last week, allowing three fourth-quarter scoring passes to Seattle in a 39-30 defeat, part of a 1-4 spread run. Indy matches up well and the underdog is 4-0 ATS in their last four meetings. Take the points on the Colts.