Indianapolis at New Orleans

The way to attack the Saints is with a ball-control offense, and Indianapolis comes into town with an excellent ground game. Mobile QB Jacoby Brissett and running back Marlon Mack anchor a ground attack that is seventh in the NFL with 133.4 yards rushing per contest. The Colts are 11-2 ATS against winning teams, as well as a 6-2-2 ATS run on the road. They've only been an underdog this large one other time this season, beating the Chiefs (19-13). The New Orleans defense has slipped badly, allowing 28 points per game the last five contests. New Orleans placed former first-round picks DE Marcus Davenport (foot) and DT Sheldon Rankins (ankle) on injured reserve this week. They come off a 48-46 loss at home to San Francisco allowing 516 yards, including 162 yards rushing. New Orleans is 30-50 ATS at home against losing teams, while the Colts are 70-44 ATS versus offenses that average 5.65+ yards per play. Play Indianapolis.