Houston at Indianapolis

Houston's defense was 14th in the NFL last year in yards allowed, sixth versus the run, 11th in points given up, sixth on third down, and piled up 46 sacks. The team signed 14 defensive free agents, including DEs Danielle Hunter and Denico Autry. and cornerbacks Jeff Okudah and C.J. Henderson. The Texans have gone four straight games UNDER in divisional play, including a 23-19 game versus the Colts. Indianapolis begins its second season with young QB Anthony Richardson. The defensive front is outstanding as the Colts were able to re-sign nose tackle Grover Stewart while tackle DeForest Buckner got a two-year extension. The run defense was 10th in the league last season in yards rushing per carry allowed (4.1), plus 11th on third down. NFL divisional underdogs are 37-15-1 ATS in Week 1, including a 17-4 ATS run. Take Indianapolis.