Houston at Indianapolis

Houston can clinch the AFC South with a win or a Jacksonville loss or tie and they can earn a playoff berth with a win OR a tie plus a Jacksonville loss plus a Pittsburgh loss or tie. Indianapolis needs some help as it clinches the AFC South with a win plus a Jacksonville loss or tie or a tie plus a Jaguars loss. The Colts clinch a playoff berth with a win OR a tie plus a Pittsburgh loss or tie. The Texans have C.J. Stroud back from concussion protocol and he threw for 213 yards and a TD and Houston held Tennessee to only 187 yards of offense and beat the Titans 26-3 on Sunday. The Texans look to avenge a 31-20 loss in the first meeting and it went OVER by 10.5 points. The Colts have gone OVER five of their past six games overall and their past five home games. Indianapolis barely got by Las Vegas 23-20 and took advantage of several mental and physical mistakes by the Raiders. The previous week the Colts were manhandled 29-10 by Atlanta and they have split their past four games. Indianapolis is No. 27 in the NFL allowing 24.5 points per game. Houston is 6-2 ATS against teams with winning records and the Colts are 6-13 ATS versus AFC South opponents. Indianapolis is 9-2 OVER after allowing more than 350 yards of offense its previous game. Take the Texans and the OVER.