Detroit at San Francisco

Detroit can't play any worse than it did on Monday night and the Lions will be focused to atone for their national embarrassment against the New York Jets. San Francisco also had high hopes for the season, but the 49ers fell flat in a 24-16 loss at Minnesota. Much-heralded Jimmy Garoppolo was only 15-of-33 for 261 yards and a touchdown but he was sacked three times and threw three interceptions. Kirk Cousins was 20-of-36 for 244 yards and two touchdowns against the 49ers defense and the Vikings totaled 116 rushing yards. The San Francisco secondary suffered some busted coverages and continued to make the glaring mistakes that has confounded fans and coaches for years and that is the defensive backs don't turn around and locate the ball. Matt Stafford will be able to take advantage of those flaws if he forgets how he played on Monday night when he threw four interceptions. Stafford still threw for 286 yards and a touchdown on 27-of-46 attempts. The Lions have gone OVER the last four times they played on Sunday when following a Monday game and they are 10-3 OVER their last 13 games overall dating to last season. The 49ers have gone OVER five of their last seven home games and they are just 4-11 ATS their last 15 home contests. Detroit is 8-2 ATS its last 10 after losing at home by at least 10 points. Look for the Lions to bounce back with the cover and also take the OVER.