Buffalo at Detroit

Josh Allen became the first player in NFL history with three passing TDs and three rushing TDs in a game, but Buffalo still lost 44-42 to the Rams on Sunday while totaling 445 yards of offense. Now that explosive offense will face Detroit's depleted defensive corps, as the Lions have four linemen listed from questionable to out for this game. The Bills are on a 6-2 ATS run, and Detroit has not covered its past two games, which were squeakers against Chicago and Green Bay. Buffalo has won nine of 11 against NFC opponents and seven of 10 road games. The Bills have averaged 33.1 points over a seven-game span, and they are #2 in the NFL with a season-scoring average of 30.5 points. Buffalo is #9 in pass defense. Allen is one of the few quarterbacks with even a better year than his counterpart in this matchup, Jared Goff. Take the Bills.