Arizona at Tennessee

This is a tough situational spot for Arizona in Week 1, opening on the East Coast. Coach Kliff Kingsbury and QB Kyler Murray are 13-18-1 together, including a losing road record. Arizona lost top pass-catching tight end Dan Arnold to free agency, who was third on the team in yards. They face a well-coached Tennessee team that has few holes. They've been 9-7, 9-7, and 11-5 the last three years with one AFC title game appearance. Workhorse power running back Derrick Henry will attack a Cardinals defense that was #18 against the run, allowing 4.6 yards per carry. QB Ryan Tannehill (33 TDs, 7 INTs) is off a terrific season, and newcomer WR Julio Jones teams with A.J. Brown to give the Titans one of the top wideout duos in the league. Tennesse is 57-33 ATS in non-conference games, so back home field in this one. Play Tennessee.