Arizona at San Francisco

I am not sure what this Arizona team has done over the last six years to warrant a road favorite role in this game. The fact is, this team has been the second coming of the Lions in regards to road futility. The Cardinals leave the desert and become become a truly awful team. They have amassed a woeful 7-38 straight-up mark the last 45 times they boarded a plane to take the road in the NFL. They have also gone just 14-32 ATS in those games. When instilled as a road favorite, they have won just once in five tries over the past six years, having lost to this San Francisco team twice last season. The Niners will have a new look on offense in two ways. J.T. O'Sullivan spent last year in Detroit with offensive coordinator Mike Martz. They Martz-O'Sullivan connection resulted in 30+ point performances in two pre-season games. The Niners added some short term help by bringing in Issac Bruce, OT Barry Sims, LB Takeo Spikes and specialist Allan Rossum. They also added DeShaun Foster, and Justin Smith. The Niners will be improved, and with the inept Cards on the road, I like the home team's chance at an outright win, or at least a very close loss.