Arizona at Jacksonville

Arizona is getting enormous respect from oddsmakers and the betting public, but this is a tough situational spot. Arizona played on the East Coast in Week 1 at Tennessee, played its home opener Sunday, and now it heads back to the East Coast to Florida. They were a 4-point favorite over Minnesota, but they squeezed out a 34-33 win when the Vikings missed a late field goal. The Cardinals are 4-10 ATS as a favorite and 5-15-1 ATS after getting 250+ passing yards in their last game. This is the second straight home game for Jacksonville, and they are playing hard for Urban Meyer and the new coaching staff. Meyer likes a balanced attack, and Arizona is #25 in run defense, #30 in yards per carry (5.4) allowed. NFL favorites like Arizona are 53-97 ATS after a game with a turnover margin of minus-2 or worse, so back the home dog. Play Jacksonville.