Arizona at Detroit

This is a high total, but the matchups are working against a high-scoring game. Arizona can run the football at will against a Detroit defense that is #27 against the run, and the Cardinals defense is one of the best in the league. They are fifth in yards allowed, fourth on third-down, and fourth in points allowed (19.5 per game). Arizona's defense bounced back strong after its two other losses, holding San Francisco to 17 points and Seattle to 13 points, both on the road. The offense loses third-leading WR DeAndre Hopkins after a bad injury Monday night. Arizona is 14-2 UNDER the total after getting 150 or fewer passing yards in the last game while Detroit's offense is #25 in total yards, #26 in passing, #29 in points (16.4 per game), and dead last on third down (31.90%). Also, NFL home teams like the Lions off a road loss of 21 or more points are 64-28 UNDER the total in the second half of the season. Play the UNDER.