Arizona at Denver

Arizona QB Kyler Murray is out after a severe injury in the last game. But QB Colt McCoy is a decent backup and his teams are 3-2 in the last five games that the veteran has started. The Cardinals have a winning road record this season and are on a 20-10 spread run on the road. They're also 23-13 ATS as an underdog, including 16-6 ATS as a road dog. Denver has been a mess on offense all year, ranked last in scoring (14.9 ppg) and on third down (28.11%). The last two times they were a pick or favored, the Broncos lost both to the Raiders (22-16) and Panthers (22-10). Denver is 4-12 ATS when the line is +3 to -3 and NFL favorites like the Broncos that average 17 or fewer points per game are 8-29 ATS. Play Arizona.