Arizona at Cleveland

Unbeaten Arizona is Top 6 in the NFL in points (31.4 per game) and yards, while the defense is allowing 19 points per game and ranked third on third-down. That point differential is second only to Buffalo. QB Kyler Murray (10 TDs, 4 INTs) leads the only team that was able to beat the Rams and it wasn't even a close, a 37-20 rout as a road dog. Arizona is 3-0 on the road, winning two of those as an underdog. The Cardinals are 7-3-1 ATS as an underdog, an impressive 10-3-2 ATS as a road dog. Cleveland QB Baker Mayfield (4 TDs, 2 INTs) hasn't got going as the Browns have leaned on their ground attack. And this defense has been shaky, ranked #22 on third down, giving up 33 to the Chiefs and 47 last week in a loss to the Chargers. And the Browns are 8-20 ATS at home against teams that average 260+ passing yards per contest. Play Arizona.