Jacksonville split two games across the Atlantic in London and lost all three road games. The offense is 29th on third down (31.82%), while the defense is 29th in yards allowed and in points surrendered (28 per game). Philadelphia is 3-0 in October, with the defense allowing an average of 12 points. They've won the last two on the road in impressive fashion, beating New York (28-3) and Cincinnati (37-17), and now come home. The offense is eighth in total yards, while the defense is seventh in yards allowed and seventh in points given up (18.9 per game). 

It's Indianapolis's second straight road game after a 23-20 loss at Houston. 39-year-old QB Joe Flacco gets the start and takes over an offense that is 19th in points scored and 20th on third down (37.62%). The defense is worse, 28th in total yards allowed and 24th on third down (42.98%). The Colts have lost six of their last nine road contests. Minnesota is home and has extra time to prepare after playing a Thursday night game. The defense is ninth in points given up and on third down, while the offense is seventh in points (26.9 per game) and 13th on third down.

Combine the Eagles (-325) and the Vikings (-225) into a 2-team parlay at -113 odds.