San Francisco is the best defensive team in the NFL, tops in total yards allowed, second against the run, and sixth in points given up (18.1 pg). The 49ers are on a 13-4 run UNDER the total, including 10-2 UNDER on natural grass. The offense is Top 10 in total yards with QB Jimmy Garoppolo (11 TDs, 4 INTs) settling in along with newcomer Christian McCaffrey. San Francisco comes off impressive wins over the Rams (31-14) and Chargers (22-16) and is 35-13 ATS on Monday night. Arizona has a weak defense, 22nd in yards allowed, 28th in points surrendered (25.8 pg), and 26th on third down (43.97%). QB Kyler Murray missed last week's game (hamstring injury) and backup QB Colt McCoy is battling a sore knee. The Cardinals will also be without tight end Zach Ertz and are 7-16 against winning teams. Parlay San Francisco (-10) + UNDER 43.

Combine the 49ers -10 (-105) and the Arizona vs. San Francisco UNDER 43 (-110) into a 2-team parlay at +273 odds.