Colo Colo comes off a 2-0 loss to Athletico Paranaense and has scored one goal in its last four games. They are ranked second-worst (2-6-3 record) in the 18-team Chile Premier Division. They are on a 1-5-2 run on the road getting outscored 11-5. Penarol has home field and is off a first-place finish in the Uruguayan Premier League (9-2-4 record) outscoring opponents 27-11 with the top-ranked defense. They are also on a dominant 12-2-4 run at home beating visitors 23-13, so back home field. Play Penarol on the moneyline.
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