Seattle at Houston

Seattle has lost five straight against winning teams. They've lost the first two games of this current road trip by a combined 15-3 at Houston. Starter Chris Flexen has not fared well against the Astros with a 1-6 record and a 4.87 ERA in eight career starts. The Mariners are 4-17 as an underdog of +125 to +175. First-place Houston is a dominant home team (32-14), 58-25 as chalk. Starter Framber Valdez (2.74 ERA) has had a strong campaign and the Astros have the best relief staff (2.72) in the big leagues. Houston is 55-23 after allowing one run or less, plus 17-4 after allowing 2 runs or less in two consecutive contests. And Houston is also 47-18 against Seattle, including 43-18 in this park. Play Houston.