Seattle at Houston

Seattle has a losing road mark and plays its sixth straight road contest. They come off a 6-2 defeat to this Houston squad and the Mariners are 8-20 when their opponent allows two or fewer runs in their previous game. Seattle is #18 in pitching ERA and goes with James Paxton, who has a 2.67 ERA at home but 4.05 on the road. Houston is tops in baseball in runs scored, seventh in pitching ERA. The Astros are 59-26 against teams whose hitters strike out seven or more times per game, plus 35-13 when the moneyline is -100 to -150. Houston starter Charlie Morton has won back-to-back decisions and six of his last seven. The balanced and powerhouse Astros are 72-34 vs. losing teams, plus on a 31-13 run against division opponents. The Mariners are also just 4-9 in the last 13 meetings in Houston. Take Houston.