San Francisco at Houston

There hasn't been a whole lot to be proud of if your a Houston Astros fan, as they are well on their way to losing 100 games for the second consecutive year. Matt Cain is at the top of a deep Giants rotation, but he has pitched to an ERA that has been over a run worse on the road than what he has done at home. The Astros may be a bit ornery here as Cain threw a perfect game at them earlier this season. Cain has a history of struggling here as he has never won in four starts, and owns a 6.52 ERA in this park. The Giants are just 3-8 in his last 11 starts as a road favorite. The Giants are also just 1-4 here in their last five. Play on Houston.