San Francisco at Cleveland

Cleveland always had trouble facing Carlos Rodon when he was in the American League, and the Guardians can't seem to escape him as they have to play San Francisco in this interleague matchup. Rodon was 2-0 with a .167 opponent batting average against Cleveland last season while allowing six earned runs in 20 innings. He also had a spectacular April in 2021 when he gave up just two earned runs on seven hits in 25 innings. In his first start this season, Colon gave up one run on three hits in five innings against Miami. The Giants are 4-2 and have allowed an average of only 2.7 runs per game. The Guardians had the day off on Thursday, and that might have cooled off their hot bats. The Giants are 22-5 following a day off and 45-17 in their last 62 road games, and the Guardians are 6-21 their past 27 as home underdogs. Take the Giants.