San Diego at San Francisco

Matt Cain went winless last season in April and thus far this year he is also 0-3. He hasn't beaten the Padres in over five years! Cain hasn't pitched horribly this sesaon, but he's getting less than stellar run support. This season the Giants are putting up just 3.3 runs per game vs. LHP like the one they'll face today (Eric Stults). Stults has a 3.31 ERA in his last three starts and dating back to last season, he's 21-13 vs. teams like San Francisco that strike out 7+ times per game. He's also 16-7 in expected low-scoring games like this one (games with a total of 7 or less). Over that same span, Cain is just 3-12 vs. losing teams. The Padres have a decent shot in this one, so take them as an underdog.