Pittsburgh at Chicago

This is simply a big-time mismatch. The Pirates have won 62% of their games. The Cubs have won just 44%. AJ Burnett makes the start for the Pirates, and he has pitched very well this season (3.12 ERA). The Cubs trot out Carlos Villanueva, who has gotten thrashed of late. In his last three starts, he has no wins and a 7.27 ERA. This season, the Pirates have feasted on weak teams, going 32-12 vs. losing opponents. When facing teams at .450 or worse, they are 29-8! Take the Pirates.