Houston at Los Angeles

Despite winning the division in 2021, Houston was a money-loser on the road (minus-$264). The Astros play their second straight road game to open the season, and the team is on a 53-60 run away from home, including 24-37 on the road when the moneyline is +125 to -125. Starter Jake Odorizzi hasn't pitched much the last two years (118 innings) with a 6-8 record and an ERA over 4.30. Last season, he had a 4.53 ERA on the road. Los Angeles is home for the second straight night and has a good young arm going in Patrick Sandoval, fanning 94 in 87 innings last season while holding batters to a .215 average. The offense is loaded with star power in Shohei Ohtani, Mike Trout, and Anthony Rendon, so back home field. Play Los Angeles.