Detroit at Chicago

Chicago is 53-27 at home after beating the Tigers 5-4 as Yoan Mercada hit a go-ahead two-run homer in the eighth and totaled three RBIs. The White Sox will send Dylan Cease to the mound, and he is 13-7 with a 3.95 ERA and hasn't allowed a run his last 10 innings. The White Sox have also won his last two starts. Cease has a 3.22 ERA and a .203 opponent batting average at home this season, and he has been nearly unhittable against Detroit, which has managed only two runs in 19 innings against him this year with a .174 batting average. Tyler Alexander has given up five runs on 16 hits in 13 innings versus the White Sox in 2021. Detroit is only 34-46 on the road and 51-114 its past 165 games versus AL Central teams, and the Tigers are 15-37 the past 52 meetings with Chicago, which is 40-16 its past 56 games against left-handed starters. Take the White Sox.