Chicago at Detroit

Chicago is the favorite to win the AL Central, and the White Sox will start Lucas Giolito, who was 11-9 with a 3.53 ERA and 201 strikeouts in 178 2/3 innings in 2021. Giolito actually had better luck on the road where he was 7-3 as opposed to 4-6 at home, and he did his best work in the second half of the season when his ERA was 2.65. His opponent batting average for the whole year was .219. Eduardo Rodriguez will make his debut with the Tigers after six seasons with Boston. Detroit has high hopes for the lefthander, but he did post a hefty 4.74 ERA last season. Chicago is 17-4 in its last 21 games in the first game of a series, and they won the past six games with Giolioto as a favorite. The White Sox are 37-16 in the last 53 meetings and 40-18 overall in their last 58 games versus lefthanded starters. Take the White Sox.