There are a couple of things to look at here, and the one that stands out the most is Chris Carpenter. Carpenter, when healthy, is one of the best pitchers in the game and at 16-4 on the season the evidence is pretty clear - he is healthy. He is already 2-0 this season vs. the Cubs and for his career he is 9-3 with a 3.02 ERA against them. That pales in contrast to Cubs' starter Ryan Dempster who owns a less than impressive 4.58 career ERA vs. the Cardinals. The Cubs have failed miserably against top pitchers, those with a WHIP of 1.15 or less, as they are just 5-21 in their last 26 games against them, and overall they are now 1-9 in their last 10 against a winning team. Dempster certainly has done nothing to stop the bleeding as he has led the Cubs to just a 2-8 mark in his last 10 starts as an underdog. Cards are 90-37 in Carpenters last 127 starts. I'll go with St. Louis in this one.
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